Diastereoselective intramolecular allyl transfer from allyl carbamate accompanied by 5-endo-trig ring closure.
نویسندگان
چکیده
To All(oc) involved: A palladium-catalyzed formal 5-endo-trig heteroannulation of enones generated in situ from amino acid derived β-keto nitriles has been realized (see scheme; Alloc=allyl carbamate). The reaction proceeds with allyl-group transfer from the carbamate protecting group to generate two new contiguous stereocenters, including one quaternary center, with high selectivity.
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عنوان ژورنال:
- Angewandte Chemie
دوره 52 9 شماره
صفحات -
تاریخ انتشار 2013